Oxymetholone was first developed in the 1960s by Syntex Pharmaceuticals. Initially created to treat anemia, it has also been used for combating diseases that lead to severe weight loss.
Its primary effects include:
Rapid weight gain
Increased appetite
Enhanced strength
Increased red blood cell count, improving oxygen transport and endurance.
Oxymetholone is a DHT-derived compound and is 17-Alpha-Alkylated (17aa), meaning it is modified to survive oral ingestion and liver metabolism.
OXYMETHOLONE PROFILE
Androgenic Index: 30–45
Anabolic Index: 320
Estrogen Level: Low (but estrogen-like effects can occur via progestin activity).
Progestogen Activity: Moderate
Hepatotoxicity: Moderate
EFFECTS
Oxymetholone is one of the most potent bulking steroids available, making it a favorite among athletes for gaining size and strength.
Key effects include:
Massive Muscle Gains: Users can gain up to 15kg (30 lbs) of muscle in a single cycle.
Enhanced Strength: Significant improvements in lifting power and performance.
Protein Synthesis: Improves recovery and muscle building.
Joint Pain Reduction: Some users report a reduction in joint discomfort.
Increased Red Blood Cell Count: Boosts endurance and workout intensity.
Enhanced Appetite: Ideal for those aiming to consume more calories for bulking.
Improved Hemoglobin Synthesis: Benefits blood health and oxygen transport.
Bone Density Support: Stimulates calcium formation, strengthening bones.
Fat Reduction: Helps decrease fat deposits, although it’s primarily for bulking.
DOSAGE AND DURATION
Cycle Duration: 3–8 weeks.
Beginners: 25–50 mg/day (not recommended).
Intermediate Users: 50–150 mg/day.
Professional Range: 100–300 mg/day (requires extreme caution).
Women: 25–50 mg/day (not recommended due to virilization risks).
Half-Life: 9 hours (active life: 16 hours).
Detection Time: 4–8 weeks (maximum reported: 12 weeks).
SIDE EFFECTS
Oxymetholone is potent but comes with notable risks, especially if misused.
Hepatotoxicity (Liver Issues):
Long-term use may lead to hepatitis, liver cirrhosis, or other severe conditions.
Symptoms include nausea, vomiting, stomach aches, and appetite suppression.
Androgenic Effects:
Oily skin, acne, and facial/body hair growth.
Male pattern baldness in predisposed individuals.
Mood and Sleep:
Potential mood swings, headaches, and insomnia.
Progestogenic Activity:
May mimic estrogen-like side effects such as water retention or gynecomastia.
Women:
Risk of virilization symptoms (e.g., deepened voice, clitoral enlargement).
Cholesterol:
Increases LDL (bad cholesterol) and lowers HDL (good cholesterol), posing cardiovascular risks.
STORAGE
Store in a dry place protected from light.
Maintain temperature at 15–25°C.
Keep out of reach of children.
POST-CYCLE THERAPY (PCT)
Begin 24 hours after the last dose of Oxymetholone.
Use Clomiphene Citrate (Clomid) for 3–4 weeks to restore natural testosterone production.
Avoid Tamoxifen Citrate, as it may enhance progestin activity.
STACKING OXYMETHOLONE
For Bulking:
Combine with Testosterone or Boldenone (Equipoise) for synergistic effects.
Avoid combining with Nandrolone or Trenbolone, as this may exacerbate progestin-related side effects.
For Strength Gains:
Combine with Testosterone to maximize power.
Stanozolol (Winstrol): A possible stack, but use caution due to increased injury risk from excessive strength gains.
KEY NOTES
Liver Support: Always use liver-protecting supplements during cycles. Avoid alcohol and other hepatotoxic substances.
Monitor Cholesterol: Regularly check lipid profiles to avoid cardiovascular issues.
Short Cycles: Limit duration to 3–8 weeks to reduce strain on the liver.
Diet and Recovery: Ensure a caloric surplus and proper PCT for optimal results and recovery.
